Ian Bicking: the old part of his blog

Null-Terminated Strings Strike Again!

From Ars Technica:

Some genetic mutations introduce a stop codon in the normal sequence. This stop codon will prematurely truncate a normal protein, which can result in defective protein functionality. As many as one third of genetic diseases may be caused by premature stop codons.

This reminds me of storing binary data in null-terminated strings (or any of a series of encoding-related bugs, and the use of sentinel values). If we ever understand genetics, I'm convinced it will be through a computational theory of genes, and that genetic (and probably viral) diseases will often exhibit bugs we've come to know from our own programming exercises.

Created 19 Oct '03
Modified 14 Dec '04

Comments:

I did some computational biology in a course at university. In one lecture on the mechanics of how chromasones turn into proteins, I read through the notes at the beginning of the lecture and said "its a programming language." found it had a scanner and a parser (the transcription and the folding process), an error correction mechanism, garbage collection, etc.

Then sat through another 49 minutes and 30 seconds of lecturing.

Its an intensely complex chemical process that brings about a fiendishly simple (from a programmers point of view) result. Love it.
# Stephen Thorne

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# felema